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Dec 11, 2025
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Virginia vs. Duke prediction, odds: 2025 ACC Championship Game picks by proven model

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SPORTS UPDATE

A spot in the College Football Playoff bracket is on the line for the No. 17 Virginia Cavaliers when they meet the Duke Blue Devils in the 2025 ACC Championship Game on Saturday. The Cavaliers finished the regular season 10-2 overall with a 7-1 ACC record. They now have an inside track for an automatic CFP bid as one of the five highest-ranked conference champions if they can get by the Blue Devils. A Duke win would create some chaos that very well could put James Madison in the field.

Kickoff from Bank of America Stadium in Charlotte is at 8 p.m. ET. The Cavaliers are 3.5-point favorites in the latest Virginia vs. Duke odds, while the over/under is 58.5. Before making any Duke vs. Virginia picks, check out the college football predictions from the SportsLine Projection Model.

New users can target theDraftKings promo codewhich offers$200 in bonus bets if your $5+ bet wins:

The model simulates every FBS game 10,000 times, and it is profitable on its top-rated money-line and over/under picks since the beginning of the 2024 season. Anybody following those college football bettingpicks at sportsbooksand on betting sitescould have seen strong returns.

Now, the model has set its sights on Virginia vs. Duke. You can visit SportsLine now to see the picks. Here are the FBS college football odds and trends for Duke vs. Virginia:

Virginia vs. Duke spread

Virginia -3.5

Virginia vs. Duke over/under

58.5 points

Virginia vs. Duke money line

Virginia -182, Duke +152

Virginia vs. Duke picks

See picks at SportsLine

Virginia vs. Duke streaming

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New users can also check out the latestFanDuel promo codeandget $150 in bonus bets at FanDuel if your $5 bet wins.

SPORTS UPDATE Why Virginia can cover

The Cavaliers, who are 8-4 against the spread this season, won at Duke on Nov. 15 in a 34-17 final, easily covering as 5-point underdogs in that matchup. Now they are small favorites a few weeks later on the neutral field. The Cavaliers also have more to play for as they are in line to head to the playoffs with a win. A Duke win guarantees the unranked Blue Devils very little since there’s a good chance they would not be one of the five highest-ranked conference champions. Virginia is a well-rounded squad that ranks second in the ACC in total defense and and fourth in total offense, so the Cavaliers are well-positioned to control this game and cover. See which team to back at SportsLine.

SPORTS UPDATE Why Duke can cover

Duke’s defense has struggled at times, but the Blue Devils have an extremely explosive offense that can keep this game within the number. Duke ranks second in the ACC in scoring offense, and that’s largely thanks to quarterback Darian Mensah, who has completed 67.5% of his passes this season for 3,450 yards, 28 touchdowns and just four interceptions. The running back duo of Nate Sheppard and Anderson Castle is one of the ACC’s best, combining for 1,300 yards and 20 touchdowns on the ground. Cooper Barkate is one of the ACC’s top receivers with a 63-978-6 line on the season. The Blue Devils appear to be the healthier team as well with Virginia ruling out 15 players and listing third-leading receiver Cam Ross among four players who are questionable. See which team to back at SportsLine.

SPORTS UPDATE How to make Duke vs. Virginia picks

SportsLine’s model is going Under on the total. It also says one side of the spread hits nearly 60% of the time. You can see the model’s pick at SportsLine.

So who wins Duke vs. Virginia, and which side of the spread hits nearly 60% of the time? Visit SportsLine now to see which side of the spread to jump on, all from the advanced model that’s up on its top-ranked money-line and total picksand find out.

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